Clinical Efficacy and Compatibility of Allogeneic Avital Tissue Transplants Sterilized with a Peracetic Acid/Ethanol Mixture

Abstract

In the course of the past 20 years a quantity of approximately 60,000 allogeneic avital tissue grafts sterilized with the peracetic acid–ethanol method (PES) were transplanted successfully. Based on a retrospective report of clinical experience of the years 1997–2001 on the overall scope of tissue grafts manufactured by the Tissue Banks of the University Hospital Charité and the German Institute for Cell and Tissue Replacement, the clinical efficacy and side effects of 18.3% (3.087/16.823) of all transplants were studied. Cancellous (1.601/3.087) and cortical (291/3.087) bone transplants as well as amnion (1.027/3.087) constituted the greatest part. In 91% of the examined patients (2.369/2.592) tissue integration ratios ranging from good up to very well could be observed. The transplant function of defect replacement or of a spacer respectively could be obtained for all types of tissue. The clinical effect caused by the transplant resulted in more than 99% of the transplants in primary integration or in the desired aim of the therapy (defect replacement, stabilization in case of palliative operations, etc.). In less than 1% (9/2.592) of cases a secondary healing occurred for cancellous bone transplantations or, revisional operations became necessary. In all cases severe side effects, in particular transmission of infectious diseases or transplant rejections, were not observed.

DOI: 10.1023/A:1024697515420

7 Figures and Tables

0100200'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

589 Citations

Semantic Scholar estimates that this publication has 589 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Pruss2004ClinicalEA, title={Clinical Efficacy and Compatibility of Allogeneic Avital Tissue Transplants Sterilized with a Peracetic Acid/Ethanol Mixture}, author={Axel Pruss and Carsten Perka and Petra Degenhardt and Ute Maronna and Karin B{\"{u}ttner-Janz and Bodo Paul and Klaus Gottlob M{\"{u}ller and Christoph Klumpp and Johannes C. Bruck and R{\"{u}diger von Versen}, journal={Cell and Tissue Banking}, year={2004}, volume={3}, pages={235-243} }