Clinical Effects of Clomiphene

@article{Bishop1965ClinicalEO,
  title={Clinical Effects of Clomiphene},
  author={Peter Maxwell Farrow Bishop},
  journal={Journal of the Royal Society of Medicine},
  year={1965},
  volume={58},
  pages={905 - 906}
}
  • P. Bishop
  • Published 1 November 1965
  • Medicine
  • Journal of the Royal Society of Medicine
Clomid clomiphene citrate is an orally active, norsteroidal compound, chemically related to TACE (trianisyl-chloroethylene), which has aestrogenic properties. It was synthesized in the Merrell Corporation laboratories in Cincinatti and was previously known by the code cipher of MRL41. Studies in rats suggested that it was likely to suppress the release of gonadotrophins in human subjects and might therefore be used as an oral contraceptive. Preliminary clinical trials undertaken by Greenblatt… 
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Tables and Topics from this paper

THE INDUCTION OF OVULATION WITH CLOMIPHENE AND ITS ASSESSMENT BY BIOLOGICAL METHODS
TLDR
Clinical experience of clomiphene citrate dates from January, 1962, and the object of this paper is to report the clinical, biological, and biochemical results obtained.
FACTORS STIMULATING THE OVARIAN FUNCTION IN MAN. A REVIEW
TLDR
The levels at which the regulatory mechanisms may be influenced for therapeutic purposes are discussed, and the indications for the use of the various agents and their most frequent side effects are briefly discussed.

References

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Action of MER-25 and of clomiphene on the human ovary.
IT APPEARS TO BE WELL ESTABLISHED that the synthetic nonsteroidal analogue of chlorotrianisene (Tace), which has been given the generic name of clomiphene citrate (MRL/41)*, is capable of stimulating
Induction of ovulation with MRL/41. Preliminary report.
TLDR
Contrary to expectations, some unsuspected and interesting biological activities were observed, one of which was the induction of ovulatorytype menses in amenorrheic anovulatory females.