Clinical Effects of Cesium Intake

@article{Melnikov2009ClinicalEO,
  title={Clinical Effects of Cesium Intake},
  author={P. Melnikov and Lourdes Z{\'e}lia Garcia Zanoni},
  journal={Biological Trace Element Research},
  year={2009},
  volume={135},
  pages={1-9}
}
The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as “high pH cancer therapy”, a complimentary alternative medicine method for cancer treatment. However, no properly confirmed tumor regression was reported so far in all probability because of neither theoretical nor experimental grounds for this proposal. The aim of the present review was to resume and discuss the material currently… 
View on Springer
ncbi.nlm.nih.gov
82 Citations
Highly Influential Citations
2
Background Citations
18

82 Citations

Reduction of radiocesium load: supplementation of Cs versus its depletion by enterosorbents.
TLDR
It is recommended to researchers studying pectin-containing enterosorbents, to verify a hypothesis, according to which Cs supplementation might be more efficient for the purpose of radiocesium washout from the organism than its depletion byEnterosorbent, that an organism saturated with stable Cs would discharge it together with previously accumulated 137Cs.
Cesium-associated hypokalemia successfully treated with amiloride
TLDR
Urinary potassium wasting responsive to amiloride therapy in a cancer patient with CAH is reported, and possible mechanisms of cesium-associated hypokalemia are discussed.
Evaluation of Plasma Trace Elements in Different Stages of Nonalcoholic Fatty Liver Disease
TLDR
Investigation of trace element levels in plasma of patients and not-patients found thallium and iron were inversely associated with insulin levels, while cesium showed a statistically significant positive association with the severity of the disease.
Dendropanax morbifera Léveille extract ameliorates cesium-induced inflammation in the kidney and decreases antioxidant enzyme levels in the hippocampus
TLDR
It is suggested that DML reduces the cesium-induced inflammatory response in the kidney and the hippocampal decrease in antioxidant enzymes levels, although it could not decrease the accumulation of cedium in the blood, kidney, and liver.
Imaging pH with hyperpolarized 13C
TLDR
This review explores the advantages and disadvantages of current pH imaging techniques and how they compare with DNP‐based approaches for the measurement and imaging of pH with hyperpolarized 13C.
Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
TLDR
It is suggested that ZA represents a reliable and non-invasive extracellular imaging sensor to localize and quantify pH, with the potential to improve understanding, diagnosis and therapy of diseases characterized by aberrant acid-base balance.
The Safety and Toxicity of Phage Therapy: A Review of Pre-Clinical and Clinical Studies
TLDR
A systematic review of safety and toxicity data associated withphage therapy in both animals and humans reported in English-language publications from 2008 – 2021 found few, but no serious, adverse events associated with phage therapy.
Maternal exposure to alkali, alkali earth, transition and other metals: Concentrations and predictors of exposure.
Content of essential and toxic trace elements in organs of obese Wistar and Zucker leprfa rats receiving quercetin.
Alkaline Materials: Sodium, Potassium, Cesium, Rubidium, Francium, and Lithium
TLDR
Property, uses, toxic effects and standards, regulations, or guidelines of exposure of various alkaline materials, including potassium and sodium, are discussed.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
Blood and tissue concentration of cesium after exposure to cesium chloride
TLDR
The high accumulation in the liver suggests that hepatotoxicity from Cs might be an initial presenting symptom in Cs-poisoning cases, as well as suggesting exposure to an alternative medical treatment.
Cesium chloride: preventive medicine for radioactive cesium exposure?
Cesium Toxicity: A Case of Self-Treatment by Alternate Therapy Gone Awry
TLDR
The authors describe a case of cesium toxicity manifested by syncope, polymorphic ventricular tachycardia, hypokalemia, and a QT interval prolonged to 650 milliseconds that resolved over 4 days following withdrawal of cedium.
The high pH therapy for cancer tests on mice and humans
  • A. K. Brewer
  • Biology
    Pharmacology Biochemistry and Behavior
  • 1984
Cesium‐Induced QT‐Interval Prolongation in an Adolescent
TLDR
A 16‐year‐old girl with metastatic hepatocellular carcinoma who experienced cesium‐induced QT‐interval prolongation after the start of a cesum chloride‐based alternative treatment regimen is described.
Effects of oral intake of cesium chloride: A single case report
  • R. Neulieb
  • Medicine
    Pharmacology Biochemistry and Behavior
  • 1984
Human metabolism of caesium
A study of the human biokinetics of caesium in two forms, i.) incorporated in foodstuff (Cs in perch and mushrooms) and ii.) in ionic state (Cs in aqueous solution) has been carried out at the…
Studies of Cs retention in the human body related to body parameters and Prussian blue administration.
Using the in-vivo monitoring data from the individuals that suffered internal contamination in the Goiânia accident, a preliminary study on the elimination of Cs from their body was conducted. It was…
The influence of renal insufficiency on caesium metabolism in man and rat (with a note on the Cs content of some biological standard materials).
TLDR
The increase in caesium levels in the patients of persons suffering from renal disorders suggests that in the first stages of the disease the patients may receive higher radiation doses from the radioisotopes of caesum than the normal population does in the case of environmental or industrial exposure.
Effects of cesium on cellular systems
TLDR
A knowledge of the biochemistry of Cs § thus became necessary in devising methods for reducing the body content of radioactive Cs + (2).
...
...