Clinical Deterioration during Antitubercular Treatment at a District Hospital in South Africa: The Importance of Drug Resistance and AIDS Defining Illnesses

@article{Pepper2009ClinicalDD,
  title={Clinical Deterioration during Antitubercular Treatment at a District Hospital in South Africa: The Importance of Drug Resistance and AIDS Defining Illnesses},
  author={Dominique J. Pepper and Kevin Brian Rebe and Chelsea Morroni and Robert J Wilkinson and Graeme Meintjes},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={150 - 158}
}
BACKGROUND Clinical deterioration on drug therapy for tuberculosis is a common cause of hospital admission in Africa. Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium tuberculosis (M.tb), co-morbid illnesses, poor adherence to therapy, tuberculosis associated-immune reconstitution inflammatory syndrome (TB-IRIS) and subtherapeutic antitubercular drug levels. It is important to derive a rapid diagnostic work-up to determine the… CONTINUE READING

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