Clinical Depression and Regulation of the Inflammatory Response During Acute Stress

@article{Miller2005ClinicalDA,
  title={Clinical Depression and Regulation of the Inflammatory Response During Acute Stress},
  author={Gregory E. Miller and Nicolas Rohleder and Cinnamon A. Stetler and Clemens Kirschbaum},
  journal={Psychosomatic Medicine},
  year={2005},
  volume={67},
  pages={679-687}
}
Objective: This study examined whether clinical depression is associated with a differential inflammatory response to an acute bout of psychological stress. Methods: A total of 72 women participated in the study; half met diagnostic criteria for clinical depression; the others had no history of psychiatric illness. The groups were matched with respect to age and ethnicity. All subjects were exposed to a 17-minute mock-job interview; blood was drawn to assess secretion and regulation of… 
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References

SHOWING 1-10 OF 75 REFERENCES
Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.
  • G. Miller, Sheldon Cohen, A. Ritchey
  • Medicine, Biology
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association
  • 2002
TLDR
There was evidence that chronic stress impaired the immune system's response to anti-inflammatory signals: the capacity of a synthetic glucocorticoid hormone to suppress in vitro production of the pro-inflammatory cytokine interleukin-6 was diminished among parents of cancer patients.
Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels.
TLDR
It is indicated that inflammatory cytokines respond to acute mental stress in humans with delayed increases, and suggest that individual differences in cytokine responses are associated with sympathetic reactivity.
The Relation of Severity of Depressive Symptoms to Monocyte-Associated Proinflammatory Cytokines and Chemokines in Apparently Healthy Men
Objective We examined the relation of severity of depressive symptoms to lipopolysaccharide-stimulated expression of monocyte-associated proinflammatory cytokines and chemokines in 53 nonsmoking,
Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress
TLDR
Investigating the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women demonstrates that despite similar free cortisol responses of men andWomen (studied in the luteal phase of their menstrual cycle) to psychossocial stress, gender may exert differential effects on the immune system by modulating GC sensitivity.
Immune activation and depression in women with rheumatoid arthritis.
TLDR
Findings provide new evidence that psychosocial factors play a significant role in autoimmune processes that underlie RA.
Pathways linking major depression and immunity in ambulatory female patients.
TLDR
Ambulatory patients with mild to moderately severe depression exhibit reduced mitogen-stimulated lymphocyte proliferative responses and altered natural killer cell cytotoxicity, which may be mediated by physical activity.
Altered glucocorticoid immunoregulation in treatment resistant depression
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