Clinical Correlates of Serum Pro-Major Basic Protein in a Spectrum of Eosinophilic Disorders and Myelofibrosis

  title={Clinical Correlates of Serum Pro-Major Basic Protein in a Spectrum of Eosinophilic Disorders and Myelofibrosis},
  author={Ching Liang Ho and H. Kito and Diane L. Squillace and Terra L. Lasho and Ayalew Tefferi},
  journal={Acta Haematologica},
  pages={158 - 164}
Background/Aims: Eosinophil cytoplasmic granules contain major basic protein (MBP), which is primarily translated from its precursor, proMBP. In this study, we evaluated the plasma level of proMBP in eosinophilic and chronic myeloproliferative disorders (MPN). Methods: The levels of plasma proMBP were measured by radioimmunoassay in 25 healthy controls, 23 patients with systemic mastocytosis (SM), 11 patients with idiopathic eosinophilia (IE) and a cohort of 170 patients with MPN which included… 
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