Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria

  title={Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria},
  author={Jacques Montplaisir and Sylvie Boucher and Gaétan Poirier and Gilles Lavigne and Odile Lapierre and Paul Lesp{\'e}rance},
  journal={Movement Disorders},
One hundred thirty‐three cases of restless legs syndrome (RLS), diagnosed with criteria recently formulated by an international study group, were studied by questionnaire and with all‐night polysomnographic recordings. Results show that RLS starts at a mean age of 27.2 years and before age 20 in 38.3% of patients. Symptoms often appear in one leg only and also involve upper limbs in about half of all cases. Most patients (94%) report sleep‐onset insomnia or numerous nocturnal awakenings due to… 
Clinical and polysomnographic features of patients with Restless Legs Syndrome.
Clinical and polysomnographic features in patients treated for restless leg syndrome are revealed and the compatibility of sleep data and clinical features are examined to examine.
Nature and variants of idiopathic restless legs syndrome: observations from 152 patients referred to secondary care in the UK
It is suggested that there is considerable delay before appropriate therapy in RLS, with a large number of patients having EDS and insomnia among others, is the commonest presenting feature.
Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational study.
The largest polysomnography study to date that compares patients with idiopathic RLS with age- and sex-matched healthy subjects demonstrates markedly fragmented sleep with deterioration of both NREM and REM sleep in RLS patients.
Restless Legs Syndrome: A Clinical Study of 55 Patients
RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.
Restless legs syndrome.
A large number of studies have now confirmed that dopamine agonists can also be effective in RLS therapy, and that this treatment seems to involve less risk for augmentation.
Prevalence of restless legs syndrome among men aged 18 to 64 years: An association with somatic disease and neuropsychiatric symptoms
Results show that restless legs syndrome is common among men and it is hypothesized that RLS may be associated with several somatic and neuropsychiatric symptoms.
Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome.
  • Jung-Won Shin, Y. Koo, Ki-Young Jung
  • Medicine, Psychology
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • 2016
The prevalence and characteristics of periodic limb movements during sleep (PLMS) in Korean patients with restless legs syndrome was lower than that observed in Western countries, but the characteristics of PLMS were not different.
Gender differences in clinical, laboratory and polysomnographic features of restless legs syndrome
Restless legs syndrome severity as measured by validated scales was worse in women, while periodic leg movements during sleep indices were higher in men, suggesting a possible gender difference in phenotypical presentation of restless legs syndrome.
Childhood‐onset restless legs syndrome
It is concluded that iron deficiency and a strong family history are characteristic of childhood‐onset restless legs syndrome.
Excessive Daytime Sleepiness in Idiopathic Restless Legs Syndrome: Characteristics and Evolution under Dopaminergic Treatment
In a series of RLS patients, EDS was common, characterized by longer sleep (PSG) and reduced sleep latencies on MSLT, and under dopaminergic treatment, both RLS severity and ESS improved.


Variable expressivity in familial restless legs syndrome.
It is concluded that there can be variable expressivity of the clinical features in familial restless legs syndrome and that there are probably some relatively nonrestless patients with prominent periodic movements in sleep who are carriers of the restless legs Syndrome gene.
Toward a better definition of the restless legs syndrome
Features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance.
Familial restless legs with periodic movements in sleep
In three subjects, the diagnosis of restless legs syndrome was confirmed by all-night sleep recordings and concomitant EMG, and Clonazepam effectively controlled restless legs in the propositus and his mother.
Nocturnal myoclonus and restless legs syndrome.
Nocturnal myoclonus (or periodic movements in sleep) consists of stereotyped sleep-related movements of the lower limbs and occasionally also upper limbs, ranging from simple dorsiflexion of the big
Sleep apnea and periodic movements in an aging sample.
The home recording indicated that the individuals with PMS slept significantly less than other older adults, and these were not clinical diagnoses.
Nocturnal sleep of narcoleptic patients: revisited.
No difference was found in patients with and without periodic movements in sleep (PMS), suggesting that PMS is not the major determinant of sleep disruption previously described in narcoleptic patients, and results indicate a possible link between REM fragmentation and cataplexy.
Myoclonus in familial restless legs syndrome.
The propositus, a 57-year-old man, suffered from repeated, intense, asymmetric flexion jerks of the lower extremities, alternating with fidgeting and friction movements of the legs at night prior to sleep and severely interfering with it.
Acute effect of nasal CPAP on periodic limb movements associated with breathing disorders during sleep.
Patients with sleep-disordered breathing and PLMS are studied in a split-night protocol to confirm the acute effects of nCPAP on PLMS and to investigate the reduced PLMS-ArI, which is a matter of future investigation.