Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes.

@article{Travi2009ClinicalPA,
  title={Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes.},
  author={Bruno L Travi and E Yaneth Osorio and Omar Abdul Saldarriaga and Horacio Cadena and Carlos Javier Tabares and Alex G. Peniche and Shuko Lee and Peter C Melby},
  journal={The American journal of tropical medicine and hygiene},
  year={2009},
  volume={81 6},
  pages={994-1003}
}
Experimental infection of dogs with Leishmania infantum has yielded heterogeneous clinical, parasitologic, and immunologic results. We studied dogs infected with 10(5) or 10(4) sand fly-derived promastigotes delivered by the intradermal (ID) or intravenous (IV) routes. Total mortality over 1 year post-infection reached 23.8%. The mortality and proportion of sustained polysymptomatic dogs was highest in the IV-10(5) group. The early appearance of polysymptoms was associated with an increased… CONTINUE READING
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