Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).

@article{Thangavelu1990ClinicalMA,
  title={Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).},
  author={Maya Thangavelu and Olofunmilayo I. Olopade and Eva Beckman and James W. Vardiman and Richard A Larson and T. Mckeithan and Michelle M Le Beau and Janet D. Rowley},
  journal={Genes, chromosomes & cancer},
  year={1990},
  volume={2 2},
  pages={147-58}
}
Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well as either a t(8;14) (three patients) or a t(8;22) (three patients). Leukemia cells from all three patients with the t(8;22) had a mature B cell phenotype (Smlg + and TdT-), whereas two of three patients with the t(8;14) had a pre-B phenotype and were Smlg-. None of the patients with the t(8;22) had a prior history of follicular lymphoma, whereas two of the three patients with the t(8;14) had had a follicular… CONTINUE READING