Clinical, immunophenotypic, and genetic analysis of adult lymphomas with morphologic features of Burkitt lymphoma.

@article{Haralambieva2005ClinicalIA,
  title={Clinical, immunophenotypic, and genetic analysis of adult lymphomas with morphologic features of Burkitt lymphoma.},
  author={Eugenia Haralambieva and E G Boerma and Gustaaf W. van Imhoff and Stefano Rosati and Ed Schuuring and Hans-Konrad Mueller-Hermelink and Philip M. Kluin and German Ott},
  journal={The American journal of surgical pathology},
  year={2005},
  volume={29 8},
  pages={1086-94}
}
A prompt distinction of Burkitt lymphoma (BL) versus diffuse large B cell lymphomas (DLBCL) has important clinical implications; however, this distinction can be difficult. We analyzed 74 adult gray zone and 10 reference pediatric BL using immunohistochemistry (Ki-67, CD10, bcl2, bcl6) and fluorescence in situ hybridization (FISH) for MYC, BCL2, and BCL6 breakpoints. Two algorithms for classification were followed: algorithm A used a two-step review by four hemato-pathologists and algorithm B a… CONTINUE READING

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