Clinical, histopathological and genetic studies in a family with fatal familial insomnia.

@article{Shi2010ClinicalHA,
  title={Clinical, histopathological and genetic studies in a family with fatal familial insomnia.},
  author={Xiao-hong Shi and Jun Han and Jin Zhang and Qi Shi and Jian-Ming Chen and Sheng-li Xia and Zhi-qiang Xie and Xiao-Jing Shen and Bing Qiang Shan and Yan-jun Lei and Song Shi and Wei Zhou and Bao-yun Zhang and Chen Ni Gao and Ying-Hui Liu and Juan Song and Yan-jun Guo and De-xin Wang and Bian-Li Xu and Xiao-Ping Dong},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2010},
  volume={10 2},
  pages={
          292-7
        }
}
We compared clinical data from two related Chinese patients with fatal familial insomnia (FFI) and collected information about their pedigree. The clinical features in the two cases were similar and included initial progressive insomnia and sympathetic activation, which persisted throughout the clinical course. A total of 135 members of this family, across seven generations, were retrospectively investigated. Eleven family members, including the two FFI cases, were found to have died with… CONTINUE READING
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