Clinical, histological and ultrastructural characteristics of a spontaneous corneal opacity in Sprague-Dawley rats.

@article{Wegener1994ClinicalHA,
  title={Clinical, histological and ultrastructural characteristics of a spontaneous corneal opacity in Sprague-Dawley rats.},
  author={Alfred R. Wegener and K Jochims},
  journal={Ophthalmic research},
  year={1994},
  volume={26 5},
  pages={296-303}
}
The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions at a room temperature of 20 +/- 2 degrees C and 55 +/- 5% humidity on a standard diet. More than 70% of the animals were found to have more or less prominent corneal opacities… CONTINUE READING

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