Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease.

@article{Zerbib2012ClinicalBN,
  title={Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease.},
  author={Frank Zerbib and Kafia Belhocine and Mireille Simon and Maylis Capdepont and François Mion and S Bruley des Varannes and J. M. Galmiche},
  journal={Gut},
  year={2012},
  volume={61 4},
  pages={
          501-6
        }
}
OBJECTIVE Approximately 30% of patients with gastro-oesophageal reflux disease (GORD) do not achieve adequate symptom control with proton pump inhibitors (PPIs). The aim of this study was to determine whether any symptom profile or reflux pattern was associated with refractoriness to PPI therapy. DESIGN Patients with typical GORD symptoms (heartburn and/or regurgitation) were included and had 24 h pH-impedance monitoring off therapy. Patients were considered to be responders if they had fewer… CONTINUE READING
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