Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.

@article{Spada1990ClinicalBA,
  title={Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.},
  author={Anna Spada and Maura Arosio and Dr. M. Bochicchio and N Bazzoni and Lucia Vallar and Mario Bassetti and Giovanni Faglia},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={71 6},
  pages={1421-6}
}
Somatic mutations in the alpha-chain (alpha s) of the stimulatory regulatory protein of adenylyl cyclase (Gs) causing constitutive activation of the enzyme have been identified in a subset of human GH-secreting pituitary adenomas. This study reports on the differences between acromegalic patients bearing tumors without (group 1; n = 51) or with (group 2; n = 29) this alteration. No difference in age, sex, clinical features, duration of the disease, or cure rate was observed between the two… CONTINUE READING