Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis.

@article{Frisbie2007ClinicalBA,
  title={Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis.},
  author={David D. Frisbie and Christopher E. Kawcak and Natasha Werpy and Richard D. Park and C Wayne McIlwraith},
  journal={American journal of veterinary research},
  year={2007},
  volume={68 3},
  pages={
          290-6
        }
}
OBJECTIVE To assess the clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced osteoarthritis in horses. ANIMALS 16 horses. PROCEDURES Osteoarthritis was induced arthroscopically in 1 middle carpal joint of all horses. In 8 placebo- and 8 ACS-treated horses, 6 mL of PBS solution or 6 mL of ACS was injected into the osteoarthritis-affected joint on days 14, 21, 28, and 35, respectively… 
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242 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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242 Citations

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Is clinical effect of autologous conditioned serum in spontaneously occurring equine articular lameness related to ACS cytokine profile?

The therapeutic benefit of ACS may be related to higher levels of IL-1Ra and IGF-1, which corroborates previous findings of considerable inter-individual variability of cytokine- and growth factor content in ACS.

Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N-acetyl glucosamine, and sodium hyaluronan.

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Comparison of the Effects of Interleukin-1 on Equine Articular Cartilage Explants and Cocultures of Osteochondral and Synovial Explants

Results suggested that there are differences in responses of culture systems to inflammatory stimulation, which may be relevant to responses of joints to inflammation in vivo and could be important to the biological relevance of in vitro research findings.

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis.

Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions

The preliminary results indicate that the treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of live in younger patients with low degree of articular degeneration.
...

References

SHOWING 1-10 OF 25 REFERENCES

Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation.

Intravenously administered hyaluronate appears to alleviate signs of lameness by interacting with synoviocytes, and by decreasing production and release of inflammatory mediators.

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

Osteoarthritis in horses and in humans is a significant social and economic problem and continued research and improvements in therapy are needed. Because horses have naturally occurring…

Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.

Recombinant human IL-1Ra exerted a dose-dependent protective effect on the development of osteophytes and cartilage lesions in vivo and could result, at least in part, from a reduction of collagenase-1 expression in OA cartilage.

Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model.

Results from this study support favourable effects of TA on degree of clinically detectable lameness, and on synovial fluid,synovial membrane, and articular cartilage morphological parameters, both with direct intra-articular administration and remote site administration as compared to placebo treatment.

Effects of 6alpha-methylprednisolone acetate on an equine osteochondral fragment exercise model.

Some beneficial effects of MPA administration on synovial fluid andsynovial membrane were identified; however, the deleterious findings contrast with those associated with triamcinolone acetonide used in a similar model, but agree with other results of M PA administration in normal and abnormal joints.

Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments.

Histologically, there were no significant detrimental effects of beta-methasone with or without exercise, but there was a tendency for more pathological change in treated joints, and intra-articular betamethas one administration in this carpal chip model was not associated with anysignificant detrimental effects in either rested or exercised horses.

In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy.

It is shown that a local increase in IL-1Ra production in OA knee joints by intraarticular injection of transduced synovial cells can reduce the progression of experimentally induced lesions.

Treatment of muscle injuries by local administration of autologous conditioned serum: a pilot study on sportsmen with muscle strains.

A preliminary study on muscle strain injuries in professional sportsmen receiving autologous conditioned serum (ACS) concluded that ACS injection is a promising approach to reduce the time to recovery from muscle injury.

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.

IL-1Ra is the first biologic agent to demonstrate a beneficial effect on the rate of joint erosion and is confirmed both the efficacy and the safety in a large cohort of patients with active and severe RA.

Evaluation of extracorporeal shock wave therapy for osteoarthritis.

A comparison of extracorporeal shockwave therapy (ESWT) to Adequanma and sham treatments in horses showed promising results, as have anecdotal reports on treating shoulder, pastern, and coffin joint OA in horses.