Clinical, Immunologic, and Molecular Factors Predicting Lymphoma Development in Sjogren’s Syndrome Patients
@article{Voulgarelis2007ClinicalIA, title={Clinical, Immunologic, and Molecular Factors Predicting Lymphoma Development in Sjogren’s Syndrome Patients}, author={Michael Voulgarelis and Fotini Skopouli}, journal={Clinical Reviews in Allergy \& Immunology}, year={2007}, volume={32}, pages={265-274} }
Among autoimmune diseases, Sjogren’s syndrome (SS) displays the highest incidence of non-Hodgkin lymphoma (NHL) development with the salivary extranodal marginal zone B cell lymphomas being the most common type. The majority of SS-associated NHLs are characterized by localized stage, indolent clinical course, and recurrence in other extranodal sites. Although the transition from a chronic inflammatory condition to malignant lymphoma is a multistep process yet poorly understood, there is…
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