Climbing fibers induce microRNA transcription in cerebellar Purkinje cells

@article{Barmack2010ClimbingFI,
  title={Climbing fibers induce microRNA transcription in cerebellar Purkinje cells},
  author={Neal H. Barmack and Zuyuan Qian and Vadim Yakhnitsa},
  journal={Neuroscience},
  year={2010},
  volume={171},
  pages={655-665}
}
The coordinated expression of as many as 100 proteins may be required to sustain simple changes in synaptic transmission. While each protein may be regulated separately, the translation of multiple proteins could be regulated by microRNAs. MicroRNAs are short non-coding RNAs that translationally repress cognate sequences in targeted mRNAs. If these targeted sequences are shared across several genes, then a single microRNA could, effectively regulate the activity of several genes in parallel… CONTINUE READING
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Long-term climbing fibre activity induces transcription of microRNAs in cerebellar Purkinje cells.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2014

The role of epigenetic-related codes in neurocomputation: dynamic hardware in the brain.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2014

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