Climbing fiber representation of the renal afferent nerve in the vermal cortex of the cat cerebellum

  title={Climbing fiber representation of the renal afferent nerve in the vermal cortex of the cat cerebellum},
  author={Gang Tong and Lee T. Robertson and John Brons},
  journal={Brain Research},
In order to understand how the cerebellum may participate in various autonomic functions, it is necessary to first determine the occurrence and distribution of the various visceral inputs in the cerebellar cortex and their relation to other cerebellar afferents. This study examines the organization of climbing fiber responses (complex spikes) of Purkinje cells elicited by electrical stimulation of the renal afferent nerve and their relationship to climbing fiber responses representing the body… 
Integration of vestibular and gastrointestinal inputs by cerebellar fastigial nucleus neurons: multisensory influences on motion sickness
The low fraction of fastigial nucleus neurons whose firing rate and responses to vestibular stimulation were affected by the administration of CuSO4 casts doubt on the notion that nauseogenic visceral inputs modulate motion sickness susceptibility principally through neural pathways that include the cerebellar fastigual nucleus.
Renal afferents and hypertension
Renal receptors, through their connections at different levels of the neuraxis, are able to reflexly influence not only cardiovascular function through changes in sympathetic nerve discharge to a variety of vascular beds and the hypothalamic release of vasopressin, but also the function of the kidney.
Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sickness
Findings support the notion that the effects of visceral inputs on motion sickness susceptibility are mediated in part through the caudal vestibular nuclei.
Connections of the caudal ventrolateral medullary reticular formation in the cat brainstem
The view that the CVLM of the cat is a multifunctional area that regulates blood pressure, produces vocalization, affects the shape of the oral cavity, and elicits contraction of particular facial muscles is consistent.
Activation of climbing fibers
The properties of olivary cells are consistent with the hypothesis that the olive is important for associating arbitrary sensory stimuli with somatosensory events and may be useful for organizing appropriate behaviors to cope with the predicted event.
Integration of vestibular and emetic gastrointestinal signals that produce nausea and vomiting: potential contributions to motion sickness
Additional neurophysiologic studies, particularly those conducted in conscious animals, will be crucial to discern the integrative processes in the brain stem that result in emesis, as much is left to be learned.
Vestibuloautonomic Interactions: A Teleologic Perspective
The visceral manifestations of motion sickness and vestibular dysfunction may be regarded as referred visceral discomfort related to gravitoinertial stimulation in the same sense that angina pectoris is a referred somatic pain related to cardiac dysfunction (Balaban 1999).
The effect of SK channel modulators on the simple spike firing frequency in discharge of cerebellar Purkinje cells in laboratory mice
The hypothesis that SK channels may be involved in the downregulation of simple spike firing frequency in Purkinje cells is confirmed, and the frequency-regulating effect of NS309 is stronger, suggesting that IK/SK channels play a decisive role in the regulation ofPurkinje cell spiking activity.
Effects of early midline cerebellar lesion on cognitive and emotional functions in the rat
The results of this study may strengthen the idea that the cerebellar vermis is involved in autism, as already suggested in the guinea pig.
Neural Substrates of Emotion as Revealed by Functional Magnetic Resonance Imaging
  • Gregory P. Lee, K. Meador, +5 authors T. Lavin
  • Psychology, Medicine
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
  • 2004
Results are consistent with theories emphasizing the importance of circuitry linking subcortical structures with mesial temporal, anterior cingulate, and frontal lobe regions in emotion and with the valence model of emotion that posits lateralized cerebral specialization for positive and negative emotional experience.


Vagal and somatic representation by the climbing fiber system in lobule V of the cat cerebellum
The results suggest that vagal input into the cerebellum could have important modulatory effects on the Cerebellar somatosensory input.
The spinal course and medullary termination of myelinated renal afferents in the rat
It is concluded that myelinated renal afferents carry information from intrarenal receptors, via the dorsal column system, to both visceral afferent and dorsal column nuclei.
Excitatory and inhibitory interactions among renal and cardiovascular afferent nerves in dorsomedial medulla.
  • R. Felder
  • Biology, Medicine
    The American journal of physiology
  • 1986
These studies show that renal afferent input interacts with cardiovascular afferentinput at neurons in the NTS region of dorsal medulla and suggest that the outcome of these interactions at the single cell level may be critically dependent on the temporal relationships among afferent impulses converging on common central synapses.
Renal afferent nerves affect discharge rate of medullary and hypothalamic single units in the cat.
It has been demonstrated that the majority of medullary and hypothalamic neurons responding to stimulation of ARN also receive an input from the CSN suggesting that certain regions of both medulla and hypothalamus can integrate peripheral information from the kidney and from cardiovascular receptors to bring about appropriate homeostatic responses.
Cerebellar corticovestibular fibers in the cat.
Abstract Lesions in various parts of the cerebellar vermal cortex were made in cats and the ensuing preterminal and terminal degeneration in the vestibular nuclei studied in silver-impregnated
Observation on the localization of mechanoreceptors in the kidney and afferent nerve fibres in the renal nerves in the rabbit.
  • A. Niijima
  • Chemistry, Medicine
    The Journal of physiology
  • 1975
It was observed that mechanoreceptors are distributed in the cranial, central and caudal portions as well as the pelvic portion of the kidney, and Histological studies show that the renal nerve possesses abundant non‐myelinated nerve fibres with a relatively small number of myelination fibres.
Electrophysiological characteristics of primate spinothalamic neurons with renal and somatic inputs.
  • W. Ammons
  • Biology, Medicine
    Journal of neurophysiology
  • 1989
Thoracolumbar STT cells in the monkey respond reliably to renal nerve stimulation and may play a role in pain that results from renal disease, and the locations of the somatic receptive fields of the cells suggest that they are responsible for the referral of renal pain to the flank and abdomen.
Brain stem regions mediating the cardiovascular responses elicited from the posterior cerebellar cortex in the rabbit.
Evidence is provided for two functionally distinct pathways from the cardiovascular region of lobule IX b to the lateral PBN and nucleus tractus solitarius/NTS.
Representation of vibrissae inputs through the climbing fiber pathway in lobule VII of the adult rat cerebellar vermis
The present study gives a detailed description of the functional characteristics and of the topographic distribution of Purkinje cell (PC) responses, mediated through the climbing fiber pathway and
Cardiovascular responses evoked from the fastigial region of the cerebellum in anaesthetized and decerebrate rabbits.
It would seem that the cardiovascular responses evoked from the vicinity of the caudal and rostral poles of the f.n. are mediated by two distinct pathways which might suggest two separate functional roles for the cerebellum in cardiovascular control in the rabbit.