Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

@article{Protais1976ClimbingBI,
  title={Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum},
  author={Philippe Protais and Jean Costentin and J. C. Schwartz},
  journal={Psychopharmacology},
  year={1976},
  volume={50},
  pages={1-6}
}
Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it… CONTINUE READING

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