Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

  title={Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum},
  author={Philippe Protais and Jean Costentin and J. C. Schwartz},
Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it… CONTINUE READING


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