Climbing a Medical Everest

  title={Climbing a Medical Everest},
  author={Alicia Ault},
  pages={2024 - 2025}
  • A. Ault
  • Published 27 June 2003
  • Sociology
  • Science
Inspired by an Oxford epidemiologist, the volunteers of the Cochrane Collaboration are sifting through mountains of data in search of medicine that works. 
The need for a rationalist turn in evidence‐based medicine
  • M. Kelly
  • Philosophy, Medicine
  • Journal of evaluation in clinical practice
  • 2018
The tensions between empiricism and rationalism are examined and it is argued for a rationalist turn in EBM to help to develop the next generation of scholarship in the field. Expand
Factors That Should Shape Clinical Strategies
Since the end of the Middle Ages and the demise of the Galenic model of human biology and illness, a reductionist, mechanistic, evidence-based paradigm has prevailed. During the several centuriesExpand
The article informs about the process of systematic review preparation, the central role of randomised clinical trials for making evidencebased decisions on benefits and harms of interventions, and discusses factors that may lead to biased evaluation of the studied interventions. Expand
The number, quality, and coverage of randomized controlled trials in nephrology.
Overall the quality of RCT reporting in nephrology is low and has not improved over the past 30 yr with unclear allocation concealment, lack of reported blinding of outcome assessors, and failure to perform "intention-to-treat analysis" particularly frequent. Expand
Research synthesis and dissemination as a bridge to knowledge management: the Cochrane Collaboration.
The work of the Cochrane Collaboration is set in historical perspective, what a Cochrane review is, initiatives for promoting worldwide dissemination of synthesized information are described, and the need for increased investment in the preparation and maintenance of Cochrane reviews is highlighted. Expand
Clinical Evidence: a useful tool for promoting evidence-based practice?
Doctors' judgement of the validity, relevance, clarity and usability of the Italian translation of Clinical Evidence after its free distribution launched by the Italian Ministry of Health seems to have been well received and to support the subsequent decision to make the Italian edition of Clinical evidence concise available to all doctors practising in the country. Expand
Patient-Reported Pain is Central to OMERACT Rheumatology Core Measurement Sets
Evidence from the OMERACT (Outcome Measures in RheumAtology Clinical Trials) consensus conferences on patient-reported pain as a key outcome measure for most rheumatologic diseases, including rheumatism, osteoarthritis, osteoporosis, back disorders, ankylosing spondylitis, and lupus is provided. Expand
To Reform U.S. Health Care, Start with Systematic Reviews
Before initiating new research, a formal synthesis of currently available knowledge should determine whether it is necessary to pursue research evidence on “what works” as an integral part of clinical practice and health policy. Expand
An empirical assessment of research practices across 163 clinical trials of tumor-bearing companion dogs
The present study confirms previous findings that clinical trials in dogs need to be improved, particularly regarding low statistical power and underreporting of design and outcomes. Expand
Follow-up for patients with colorectal cancer after curative-intent primary treatment.
Efforts to diagnose and treat recurrent colorectal cancer reached a peak with planned “second-look” laparotomy for patients with various intra-abdominal cancers judged to be at high risk for local-regional relapse, and the concept of the randomized trial was introduced in the mid-twentieth century. Expand