Climbing Fiber Signaling and Cerebellar Gain Control

  title={Climbing Fiber Signaling and Cerebellar Gain Control},
  author={Gen Ohtsuki and Claire Piochon and Christian R W Hansel},
  booktitle={Front. Cell. Neurosci.},
The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term depression (LTD) at parallel fiber-Purkinje cell synapses have become hallmark features of cerebellar physiology. However, the key role of climbing fiber signaling in cerebellar motor learning has been challenged by recent reports of forms of synaptic… CONTINUE READING
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