Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals.

Abstract

The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores. Reaction of azide-functionalized molecules with alkyne prochelators by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC; click reaction) enables the simultaneous synthesis and conjugation… (More)
DOI: 10.3390/molecules18033206

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@article{Kluba2013ClicktoChelateDO, title={Click-to-Chelate: development of technetium and rhenium-tricarbonyl labeled radiopharmaceuticals.}, author={Christiane A Kluba and Thomas L Mindt}, journal={Molecules}, year={2013}, volume={18 3}, pages={3206-26} }