Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.

@article{Lewis2002ClickCI,
  title={Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks.},
  author={Warren G Lewis and Luke G. Green and Flavio Grynszpan and Zoran Radic and Paul R Carlier and Palmer Taylor and M G Finn and K. Barry Sharpless},
  journal={Angewandte Chemie},
  year={2002},
  volume={41 6},
  pages={1053-7}
}
The generation and/or optimization of lead compounds by combinatorial methods has become widely accepted in medicinal chemistry, and is the subject of continued improvement.[1±3] However, most combinatorial strategies remain dependent upon iterative cycles of synthesis and screening. The direct involvement of the target, usually a receptor or enzyme, in the selection, evolution, and screening of drug candidates can accelerate the discovery process by shortcircuiting its traditionally stepwise… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Angew . Chem . 2001 , 113 , 1824 ± 1826

  • T. H. Marsilje, H. Cai, +8 authors M. G. Finn
  • Angew . Chem . Int . Ed .
  • 2001

Combinatorial Chemistry

  • S. R. Wilson, A. W. Czarnik
  • Wiley, New York
  • 1997
1 Excerpt

F

  • E. Albert
  • Phillip in Alzheimer Disease: FromMolecular…
  • 1996
1 Excerpt

Profiles, Pathways, and Dreams (Ed.

  • R. Huisgen
  • American Chemical Society,
  • 1994

in Synergism and Antagonism in Chemotherapy

  • D. C. Rideout, T. Calogeropoulou
  • Academic Press, Orlando
  • 1991
2 Excerpts

Similar Papers

Loading similar papers…