Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.

@article{Banerjee2013ClickCB,
  title={Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.},
  author={Ashutosh Banerjee and Simone Maschauer and Harald H{\"u}bner and Peter Gmeiner and Olaf Prante},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 22},
  pages={
          6079-82
        }
}
Taking advantage of click chemistry, a library of N-arylpiperazinylmethyl triazoles bearing fluoro substituted appendages was synthesized and the target compounds were investigated for dopamine and serotonin receptor binding. With the aim to bias their hydrophilicity and to optimize their D4 receptor affinity and selectivity, a concise series of triazoles containing fluoroalkyl, fluoroalkoxy, fluoroalkoxyphenyl, and deoxyfluoroglucosyl substituents was studied. The D4 receptor affinity and… CONTINUE READING
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