Click Triazoles

  title={Click Triazoles},
  author={Janine Cossy and Dieter Enders and Steven V. Ley and G. Mehta and Kyriacos C Nicolaou and Larry E. Overman and Albert Padwa and Click Triazoles and Benjamin R. Buckley and Yuanyuan Chen and H.-F. Chow and James D. Crowley and A. Heaney and Abubakar S. Jalloh and Thomas Lecourt and S. Lee and Chuiman Lo and David A McMorran and Luca Mignani and Simon Watkinson and Pengcheng Zheng and Y. Zhou},
  journal={Click Triazoles},
The chapter concentrates on mechanistic aspects of thermal and metal catalysed reactions of organic azides and alkynes, particularly terminal alkynes, that result in the formation of 1,2,3-triazoles. 
6 Citations
A facile access for the synthesis of 1-hetero(aryl)-1,2,3-triazoles linked to equol under mild conditions
Abstract We herein report a convenient methodology for the synthesis of 1-hetero(aryl)-1,2,3-triazoles linked with equol by utilizing copper-catalyzed azide-alkyne cycloaddition reaction under
Double Cu-Catalyzed Direct Csp3 -H Azidation/CuAAC Reaction: A Direct Approach towards Demanding Triazole Conjugates.
The first one-pot procedure for the double copper(I)-catalyzed oxidative Csp3 -H azidation-CuAAC process, implying unstable azide intermediates and easy-to-remove reagents under water-tolerant
Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent
A new type of UV/“blue light-emitting” materials with better photophysical properties was obtained using 2,5-diaryl substituted 4-azido-1,2,3-triazoles bearing ortho-propargyloxy substituents in the 5 position.
Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions
This work represents the initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, and two types of alkynes are shown to undergo rapid CuAAC reactions under both copper(II)- (via an induction period) and copper(I)- catalyzed conditions.


Metal ions recognition by 1,2,3-triazolium calix[4]arene esters synthesized via click chemistry
Two triazole-modified calix[4]arene diesters were synthesized via Huisgen 1,3-dipolar cycloaddition between azides esters and alkynylcalixarenes. Their structures had been deduced from 1H NMR,
Facile derivatization of azide ions using click chemistry for their sensitive detection with LC-MS.
By employing a click reaction, a novel method was developed for the sensitive detection of inorganic azides at as low as 21 ppb.
‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features
Bidentate 1-O-methyl-α-d-pyranoglucosides bearing two triazolyl α-ketoester groups on the 2,6- or 3,4-positions of sugar scaffold were efficiently synthesized via Cu(I)-catalyzed azide-alkyne
A selective fluorescent probe of Hg2+ based on triazole-linked 8-oxyquinoline calix[4]arene by click chemistry
Calixarene compound 1 with two 8-oxyquinoline subunits was synthesised using ‘click’ chemistry. Compound 1 shows strong fluorescence quenching by Hg2+ and lower pH. Using the fluorescence behaviour
Triazole-ester modified silver nanoparticles: click synthesis and Cd2+ colorimetric sensing.
Triazole-ester modified silver nanoparticles were designed and synthesized through click chemistry, which provided a highly selective colorimetric sensor for Cd2+.
Steroidal 1,2,3-triazole-based sensors for Hg2+ ion and their logic gate behaviour
Abstract 1,2,3-Triazole-based sensors for Hg 2+ ion have been developed which exhibit NOR and OR logic gate behaviour on using Hg 2+ and H + as inputs.
Synthesis and binding ability of 1,2,3-triazole-based triterpenoid receptors for recognition of Hg(2+) ion.
A novel type of receptors based on 1,2,3-triazole glycyrrhetinic acid derived from natural triterpenoid molecules has been synthesized via click chemistry and they showed high selectivity and
A click-generated triazole tethered ferrocene-pyrene dyad for dual-mode recognition of the pyrophosphate anion.
The ferrocene-pyrene dyad 3 is able to selectively sense the pyrophosphate anion and can be inferred from either the redox-shift or emission intensity ratio of the pyrene monomer to the excimer emission bands in both the neutral and oxidized forms of the receptor upon complexation.
A facile method to clickable sensing polymeric nanoparticles.
Clickable biocompatible nanoparticles were prepared in a one-pot process by microemulsion polymerization using acrylamide, N,N'-methylene bisacrylamide and either
A Pyrenyl-Appended Triazole-Based Calix(4)arene as a Fluorescent Sensor for Iodide Ion †
Any deficien-cy of iodide can give rise to serious diseases such as enlarged goitres or mental retardment. Iodine is a biologically essential element in seawater, where it exists predominantly as the