Click-Crosslinked Injectable Gelatin Hydrogels.

Abstract

Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.

DOI: 10.1002/adhm.201500757

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Cite this paper

@article{Koshy2016ClickCrosslinkedIG, title={Click-Crosslinked Injectable Gelatin Hydrogels.}, author={Sandeep Tharian Koshy and Rajiv M Desai and Pascal Joly and Jianyu Li and Rishi K Bagrodia and Sarah A. Lewin and Neel S Joshi and David Mooney}, journal={Advanced healthcare materials}, year={2016}, volume={5 5}, pages={541-7} }