Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.

@article{Griffin2017ClemizoleAM,
  title={Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome.},
  author={Aliesha Griffin and Kyla R. Hamling and Kelly G. Knupp and SoonGweon Hong and Luke P. Lee and Scott C Baraban},
  journal={Brain : a journal of neurology},
  year={2017},
  volume={140 3},
  pages={
          669-683
        }
}
Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed language and motor development, sleep disturbances, anxiety-like behaviour, severe cognitive deficit and an increased risk of fatality. It is primarily caused by de novo mutations of the SCN1A gene encoding a neuronal voltage-activated sodium channel. Zebrafish with a mutation in the SCN1A homologue recapitulate spontaneous seizure activity and mimic the convulsive behavioural movements observed in Dravet… CONTINUE READING
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