Clementine juice has the potential for drug interactions – In vitro comparison with grapefruit and mandarin juice

@article{Theile2017ClementineJH,
  title={Clementine juice has the potential for drug interactions – In vitro comparison with grapefruit and mandarin juice},
  author={Dirk Theile and Nicolas Hohmann and Dominik Kiemel and Giuseppe Gattuso and Davide Barreca and Gerd Mikus and Walter Emil Haefeli and Vedat Schwenger and Johanna Weiss},
  journal={European Journal of Pharmaceutical Sciences},
  year={2017},
  volume={97},
  pages={247–256}
}
&NA; Adverse drug interactions due to grapefruit juice are well known prompting warnings even in drug labels. Similar issues have not been reported for clementines and available data is scarce, despite of genetic descent. We observed substantially increased tacrolimus trough concentrations in a renal transplant patient consuming high clementine amounts and, thus, scrutinised the effects of clementine juice on drug metabolism and drug transporters in vitro and compared it to the effects of… Expand
Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro.
TLDR
The results demonstrated that the flavonoid fraction of clementine juice provoked induction of several genes and inhibition of both CYP3A4 and CYP1A2, matching effects observed with whole clementin juice. Expand
A follow‐up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A‐dependent midazolam clearance
  • N. Hohmann, G. Mikus, +4 authors J. Weiss
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2019
TLDR
Two single case experiments with repetitive phenotyping of CYP3A activity were conducted to assess the clinical relevance of clementine‐drug interaction and found that one cannot assure a potential drug interaction due to the clementines, but prescribers should be cautious unless further data emerges. Expand
The aglycone diosmetin has the higher perpetrator drug-drug interaction potential compared to the parent flavone diosmin
Abstract The flavone diosmin is part of everyday nutrition but also marketed as medicine or nutritional supplement against various diseases. Although the manufacturers declare safe administration,Expand
Phytomedicines: Synergistic and antagonistic phytometabolites-drug interactions
TLDR
This chapter is structured in two parts, based on a study of the production mode as well as the factors favoring the production of phytometabolite-drug interactions, comprising the mechanism of producing the interaction between grapefruit juice and diclofenac (DCF) based on the pharmacokinetic parameters determined experimentally. Expand
Potential Risk of Food-Drug Interactions: Citrus Polymethoxyflavones and Flavanones as Inhibitors of the Organic Anion Transporting Polypeptides (OATP) 1B1, 1B3, and 2B1
TLDR
All flavonoids investigated might contribute to the intestinal OATP2B1-based interactions with drugs observed with citrus juices or fruits, but there might be a risk when they are consumed as medicines or as dietary supplements. Expand
The Effect of Single-Dose Ougan Juice Application on the Pharmacokinetics of Erlotinib
TLDR
Ougan juice affected the PK spectrum of erlotinib in rats by improving the bioavailability of the drug and significantly increasing its plasma concentration. Expand
Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p‐Synephrine
  • S. Stohs
  • Medicine
  • Phytotherapy research : PTR
  • 2017
TLDR
This review, as well as several other assessments published in recent years, has concluded that bitter orange extract and p‐synephrine are safe for use in dietary supplements and foods at the commonly used doses. Expand
Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties
TLDR
This review analyzes the biochemical, pharmacological, and biological properties of Citrus flavones, emphasizing their occurrence in Citrus spp. Expand
Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways
TLDR
Evidence indicates that tangeretin acts through several mechanisms including growth inhibition, induction of apoptosis, autophagy, antiangiogenesis, and estrogenic-like effects, which can lead to significant health care improvement in cancer survivors. Expand
Insights into the development of grapefruit nutraceutical powder by spray drying: physical characterization, chemical composition and 3D intestinal permeability.
TLDR
It is established that the formulation of grapefruit powder has great potential as a nutraceutical food, with spray drying being a good alternative technique in the food industry. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 83 REFERENCES
Grapefruit-Drug Interactions
TLDR
The aim of this review is to outline the mechanisms of grapefruit-drug interactions and present a comprehensive summary of those agents affected and whether they are likely to be of clinical relevance. Expand
Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.
TLDR
This study suggests considering concentrations of components with a potential for drug interactions in GFJ-drug interaction studies, as the concentration of potentially contributing compounds may crucially influence the magnitude of observed interaction and impair direct comparison of studies in which different juices have been used. Expand
In vitro interactions with repeated grapefruit juice administration--to peel or not to peel?
TLDR
GFJ containing no peel extract may have a lower potential for interactions with CYP3A4 or P-glycoprotein. Expand
Naringin is a Major and Selective Clinical Inhibitor of Organic Anion‐Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice
TLDR
Naringin most probably directly inhibited enteric OATP1A2 to decrease oral fexofenadine bioavailability and may be the first report of a single dietary constituent clinically modulating drug transport. Expand
Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity.
TLDR
All six furanocoumarins showed stronger CYP3A inhibitory potencies after preincubation in the presence of NADPH, suggesting that both competitive and mechanism-based inhibition occur in a grapefruit juices-drug interaction. Expand
Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.
TLDR
The in vitro data suggest that compounds present in grapefruit juice are able to inhibit the P-gp activity modifying the disposition of drugs that are P- gp substrates such as talinolol. Expand
Co-administration of grapefruit juice increases bioavailability of tacrolimus in liver transplant patients: a prospective study
TLDR
In the setting of a controlled clinical study, the co-administration of GFJ with FK506 increased the bioavailability of FK505, however, the concentration of tacrolimus should be closely monitored and the dose adjusted to a treatment window. Expand
Grapefruit Juice and its Constituents Augment Colchicine Intestinal Absorption: Potential Hazardous Interaction and the Role of P-Glycoprotein
TLDR
GFJ may augment colchicine oral bioavailability, suggesting inhibition of efflux transport, rather than metabolizing enzyme, in the absence/presence of known P-gp inhibitors. Expand
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects
TLDR
The effect of grapefruit juice decreased time dependently and lasted for at least 3 days after intake of nisoldipine, and the model gave predicted values in good agreement with the observed values. Expand
Ingredients in fruit juices interact with dasatinib through inhibition of BCRP: a new mechanism of beverage-drug interaction.
TLDR
The novel finding that FJ ingredients strongly inhibit BCRP may represent a new mechanism of beverage-drug interaction and in vivo investigations are warranted to evaluate the B CRP-mediated FJ-TKI interaction. Expand
...
1
2
3
4
5
...