Cleland's reagents block lethal and hypnotic effects of pentobarbital.

  title={Cleland's reagents block lethal and hypnotic effects of pentobarbital.},
  author={Laimonis Gailis},
  journal={European journal of pharmacology},
  volume={292 1},
We studied the effect of the reducing agents dithiothreitol and dithioerythritol (Cleland's reagents) on the hypnotic and toxic effects of pentobarbital in rodents. In pentobarbital anesthetized rats (50 mg/kg), the i.v. infusion of dithioerythritol (84 mumol/kg/min for 10 min) accelerated the return of eyeblink and righting reflexes (to 4 +/- 1 min vs. 22 +/- 2 min,k and 15 +/- 1 vs. 65 +/- 8 min respectively (P < 0.001). In mice receiving lethal doses of pentobarbital, the 4 h LD50 was 128… CONTINUE READING

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