Cleft Palate Is Caused by CNS Dysfunction in Gad1 and Viaat Knockout Mice

  title={Cleft Palate Is Caused by CNS Dysfunction in Gad1 and Viaat Knockout Mice},
  author={Won-Jong Oh and Joby J. Westmoreland and R Patrick Summers and Brian Gene Condie},
  booktitle={PloS one},
BACKGROUND Previous studies have shown that disruption of GABA signaling in mice via mutations in the Gad1, Gabrb3 or Viaat genes leads to the development of non-neural developmental defects such as cleft palate. Studies of the Gabrb3 and Gad1 mutant mice have suggested that GABA function could be required either in the central nervous system or in the palate itself for normal palatogenesis. METHODOLOGY/PRINCIPAL FINDINGS To further examine the role of GABA signaling in palatogenesis we used… CONTINUE READING


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