Cleavage specificity of human skin type IV collagenase (gelatinase). Identification of cleavage sites in type I gelatin, with confirmation using synthetic peptides.

Abstract

Type IV collagenase (gelatinase) readily cleaves denatured collagen into very small peptides. Large cyanogen bromide fragments (25 kDa) of type I collagen are degraded at the same rate as the complete alpha-chain. A number of the gelatinolytic cleavage sites of alpha 1(I)CB7 and alpha 1(I)CB8, representing 50% of the collagen alpha-chain, were determined by… (More)

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Cite this paper

@article{Seltzer1990CleavageSO, title={Cleavage specificity of human skin type IV collagenase (gelatinase). Identification of cleavage sites in type I gelatin, with confirmation using synthetic peptides.}, author={Jonathan Seltzer and Kathryn T Akers and Helen Weingarten and Gerald Grant and David McCourt and Adi Eisen}, journal={The Journal of biological chemistry}, year={1990}, volume={265 33}, pages={20409-13} }