Cleavage of the calpain inhibitor, calpastatin, during apoptosis

@article{PrnAres1998CleavageOT,
  title={Cleavage of the calpain inhibitor, calpastatin, during apoptosis},
  author={M. Isabella P{\"o}rn-Ares and Afshin Samali and Sten Orrenius},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={1028-1033}
}
Calpain activity is thought to be essential for the execution of apoptotic cell death in certain experimental models. In the present study, the physiological inhibitor of calpain, calpastatin, was found to be cleaved in three different apoptotic systems. The 110–120 kDa calpastatin protein of Jurkat T-lymphocytes and U937 monocytic leukemia cells was cleaved to a 65–70 kDa form after the induction of apoptosis with anti-CD95 monoclonal antibody, staurosporine or TNF. Cleavage of calpastatin in… CONTINUE READING
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