Cleavage of the Pt–S bond of thiolated terpyridine–platinum(ii) complexes by copper(ii) and zinc(ii) ions in phosphate buffer

Abstract

Many efforts in the development of platinum complexes as anticancer drugs have been contemplated in order to reduce the cytotoxicity and to improve the platin drug-resistance.1 Since sulfur-containing compounds such as glutathione and metallothioneins are rich in cells, the formation of the S–Pt bond is generally believed to be one of the major mechanisms… (More)

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