Cleavage of the Escherichia coli lexA protein by the recA protease.

  title={Cleavage of the Escherichia coli lexA protein by the recA protease.},
  author={John W. Little and Susan H. Edmiston and Laura Z. Pacelli and David W. Mount},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 6},
The recA and lexA proteins of EScherichia coli are involved in a complex regulatory circuit that allows the expression of a diverse set of functions after DNA damage or inhibition of DNA replication. Exponentially growing cells contain a low level of recA protein, and genetic evidence suggests that lexA protein is involved in its regulation, perhaps as a simple repressor. Recent models for recA derepression after DNA damage have suggested that an early event in this process is the proteolytic… CONTINUE READING


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