Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.

@article{Knnapuu2014CleavageOT,
  title={Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.},
  author={Jaana K{\"u}nnapuu and Petra M Tauscher and Nina Tiusanen and Minh Anh H Nguyen and Ari L{\"o}ytynoja and Kavita Arora and Osamu Shimmi},
  journal={Developmental biology},
  year={2014},
  volume={389 2},
  pages={
          149-59
        }
}
Dorsoventral patterning of the Drosophila embryo is regulated by graded distribution of bone morphogenetic proteins (BMPs) composed of two ligands, decapentaplegic (Dpp) a BMP2/4 ortholog and screw (Scw) a BMP5/6/7/8 family member. scw(E1) encodes an unusual allele that was isolated as a dominant enhancer of partial loss-of-function mutations in dpp. However, the molecular mechanisms that underlie this genetic interaction remain to be addressed. Here we show that scw(E1) contains a mutation at… CONTINUE READING
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