Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels

@article{Stanley1997CleavageOS,
  title={Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels},
  author={Elise F. Stanley and R. R. Mirotznik},
  journal={Nature},
  year={1997},
  volume={385},
  pages={340-343}
}
Neurotransmitter release into the synapse is stimulated by calcium influx through ion channels that are closely associated with the transmitter release sites1,2. This link may involve the membrane protein syntaxin, which is known to be associated with the release sites and to bind to the calcium channels3,4. There is evidence that presynaptic calcium channels are downregulated by second messenger pathways involving G proteins5,6. Here we use the patch-clamp technique to test whether calcium… CONTINUE READING
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