Cleavage of recombinant human corticotropin-releasing factor (CRF)-binding protein produces a 27-kilodalton fragment capable of binding CRF.

@article{Woods1999CleavageOR,
  title={Cleavage of recombinant human corticotropin-releasing factor (CRF)-binding protein produces a 27-kilodalton fragment capable of binding CRF.},
  author={Russell J. Woods and Charles F. Kemp and J. David and Ian Sumner and Philip J. Lowry},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 8},
  pages={2788-94}
}
CRF is both a peripheral and a central mediator of inflammation, the activity of which is modified by the presence of a 37-kDa binding protein (CRF-BP). The objective of this study was to measure and characterize this protein in the synovial fluid of rheumatoid arthritis patients and to observe the effects of this inflammatory condition on its structure and properties. Measured by immunoradiometric assays, the mean CRF-BP concentration in synovial fluid from 27 arthritic patients was 0.51 nmol… CONTINUE READING

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