Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

@article{Pang2004CleavageOP,
  title={Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity},
  author={Petti T. Pang and Henry K Teng and Eugene Zaitsev and Newton T Woo and Kazuko Sakata and Shushuang Zhen and Kenneth K. Teng and Wing-Ho Yung and Barbara L. Hempstead and Bai Lu},
  journal={Science},
  year={2004},
  volume={306},
  pages={487 - 491}
}
Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse… 
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References

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TLDR
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