Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses.

@article{Lei2013CleavageOI,
  title={Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses.},
  author={Xiaobo Lei and Xia Xiao and Qinghua Xue and Qi Jin and Bin He and Jianwei Wang},
  journal={Journal of virology},
  year={2013},
  volume={87 3},
  pages={1690-8}
}
Enterovirus 71 (EV71) is a positive-stranded RNA virus which is capable of inhibiting innate immunity. Among virus-encoded proteins, the 3C protein compromises the type I interferon (IFN-I) response mediated by retinoid acid-inducible gene-I (RIG-I) or Toll-like receptor 3 that activates interferon regulatory 3 (IRF3) and IRF7. In the present study, we report that enterovirus 71 downregulates IRF7 through the 3C protein, which inhibits the function of IRF7. When expressed in mammalian cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection

Front. Microbiol. • 2018
View 11 Excerpts
Highly Influenced

Immune Evasion of Enteroviruses Under Innate Immune Monitoring

Front. Microbiol. • 2018
View 6 Excerpts
Highly Influenced

Association of EV71 3C polymorphisms with clinical severity.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi • 2018
View 2 Excerpts

Enterovirus A71 Proteins: Structure and Function

Front. Microbiol. • 2018
View 3 Excerpts

Similar Papers

Loading similar papers…