Cleavage of focal adhesion kinase by caspases during apoptosis.

  title={Cleavage of focal adhesion kinase by caspases during apoptosis.},
  author={L P Wen and Jimothy A Fahrni and S Troie and Jun-Lin Guan and Kim Orth and Glenn Rosen},
  journal={The Journal of biological chemistry},
  volume={272 41},
Apoptotic cells undergo characteristic morphological changes that include detachment of cell attachment from the substratum and loss of cell-cell interactions. Attachment of cells to the extracellular matrix and to other cells is mediated by integrins. The interactions of integrins with the extracellular matrix activates focal adhesion kinase (FAK) and suppresses apoptosis in diverse cell types. Members of the tumor necrosis family such as Fas and Apo-2L, also known as tumor necrosis factor… CONTINUE READING


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