Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.

@article{Millien2013CleavageOF,
  title={Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.},
  author={Valentine Ongeri Millien and Wen Lu and Joanne A Shaw and Xiaoyi Yuan and Garbo Mak and Luz E Roberts and Li-zhen Song and J Morgan Knight and Chad J Creighton and Amber U. Luong and Farrah Kheradmand and David B Corry},
  journal={Science},
  year={2013},
  volume={341 6147},
  pages={792-6}
}
Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression of allergic inflammation and diseases such as asthma. A mechanism that links these inflammatory mediators is essential for explaining the fundamental basis of allergic disease but has been elusive. Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity. These outcomes were induced by proteinase cleavage of the… CONTINUE READING
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