Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.

@article{Gradi2004CleavageOE,
  title={Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.},
  author={Alessandra Gradi and Nicole Foeger and Rebecca Strong and Yuri V. Svitkin and Nahum Sonenberg and Tim Skern and Graham J Belsham},
  journal={Journal of virology},
  year={2004},
  volume={78 7},
  pages={3271-8}
}
Foot-and-mouth disease virus (FMDV) induces a very rapid inhibition of host cell protein synthesis within infected cells. This is accompanied by the cleavage of the eukaryotic translation initiation factor 4GI (eIF4GI). The cleavage of the related protein eIF4GII has now been analyzed. Within FMDV-infected cells, cleavage of eIF4GI and eIF4GII occurs with similar kinetics. Cleavage of eIF4GII is induced in cells and in cell extracts by the FMDV leader protease (L(pro)) alone, generating… CONTINUE READING

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