Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma.

@article{Yamamoto2005CleavageOC,
  title={Cleavage of carcinoembryonic antigen induces metastatic potential in colorectal carcinoma.},
  author={Yasuko Yamamoto and E. Hirakawa and S. Mori and Y. Hamada and N. Kawaguchi and N. Matsuura},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 1},
  pages={
          223-9
        }
}
Carcinoembryonic antigen (CEA), a widely used tumor marker, is attached by a glycosylphosphatidylinositol (GPI) anchor motif to the cell membrane. Recent study suggested that membrane-bound CEA might be cleaved by glycosylphosphatidylinositol-phospholipase D (GPI-PLD). We studied the effect of GPI-PLD on the cleavage of CEA to elucidate the implication for metastatic potential in colorectal carcinoma cells. CEA amount of conditioned medium was changed by suramin and phenanthroline (activator… Expand
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Inhibition of CEA release from epithelial cells by lipid A of Gram-negative bacteria
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