Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.

@article{Ellerby1999CleavageOA,
  title={Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.},
  author={Lisa M. Ellerby and Rebecca L. Andrusiak and Cheryl L Wellington and Abigail S. Hackam and Stephanie S Propp and Jon D Wood and Alan H. Sharp and Robert L. Margolis and Christopher A. Ross and Guy Salvesen and Michael R. Hayden and Dale E. Bredesen},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 13},
  pages={8730-6}
}
Dentatorubropallidoluysian atrophy (DRPLA) is one of eight autosomal dominant neurodegenerative disorders characterized by an abnormal CAG repeat expansion which results in the expression of a protein with a polyglutamine stretch of excessive length. We have reported recently that four of the gene products (huntingtin, atrophin-1 (DRPLA), ataxin-3, and… CONTINUE READING