Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion.


In the present study, we sought to determine whether low-grade, chronic vascular insufficiency induced in a rodent model of chronic cerebrohypoperfusion is sufficient, in and of itself, to trigger cleavage of the amyloid precursor protein (APP) into beta A-sized fragments. We report that chronic two vessel occlusion (2VO) results in progressive accumulation… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.