Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.

@article{Rosebeck2011CleavageON,
  title={Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.},
  author={Shaun Rosebeck and Lisa M. Madden and Xiaohong Jin and Shufang Gu and Ingrid J. Apel and Alex Appert and Rifat A. Hamoudi and Heidi Noels and Xavier Sagaert and Peter Van Loo and Mathijs Baens and Ming-Qing Du and Peter C. Lucas and Linda M. McAllister-Lucas},
  journal={Science},
  year={2011},
  volume={331 6016},
  pages={468-72}
}
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-κB-inducing kinase (NIK) at arginine 325. NIK cleavage requires the concerted actions of both fusion partners and generates a C… CONTINUE READING