Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.

@article{Gutwein2005CleavageOL,
  title={Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.},
  author={Paul Gutwein and Alexander Stoeck and Svenja Riedle and Daniela Gast and Steffen Runz and Thomas P. Condon and Alexander Marm{\'e} and Minh-Chau Phong and Otwin Linderkamp and Alexander Skorokhod and Peter Altevogt},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 7},
  pages={2492-501}
}
PURPOSE The L1 adhesion molecule (CD171) is overexpressed in human ovarian and endometrial carcinomas and is associated with bad prognosis. Although expressed as a transmembrane molecule, L1 is released from carcinoma cells in a soluble form. Soluble L1 is present in serum and ascites of ovarian carcinoma patients. We investigated the mode of L1 cleavage and the function of soluble L1. EXPERIMENTAL DESIGN We used ovarian carcinoma cell lines and ascites from ovarian carcinoma patients to… CONTINUE READING

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