Cleavage of Insertion/Deletion Mismatches, Flap and Pseudo-Y DNA Structures by Deoxyinosine 3′-Endonuclease from Escherichia coli*

@article{Yao1996CleavageOI,
  title={Cleavage of Insertion/Deletion Mismatches, Flap and Pseudo-Y DNA Structures by Deoxyinosine 3′-Endonuclease from Escherichia coli*},
  author={Ming Dong Yao and Yoke Wah Kow},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={30672 - 30676}
}
  • M. Yao, Y. Kow
  • Published 29 November 1996
  • Biology, Chemistry
  • The Journal of Biological Chemistry
Deoxyinosine 3′-endonuclease, an Escherichia coli repair enzyme that recognizes and cleaves DNA containing deoxyinosine and base mismatches, can cleave heteroduplexes containing a hairpin or unpaired loop. These DNA structures, referred to as insertion/deletion mismatches (IDM), are abnormal intermediate structures generated during replication of repetitive DNA sequences. In addition, the enzyme also cleaved the 5′-single-stranded tails of flap and pseudo-Y DNA structures, suggesting that… 
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DNA is constantly damaged by endogenous and environmental influences. Deaminated adenine (hypoxanthine) tends to pair with cytosine and leads to the A:T→G:C transition mutation during DNA…
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References

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  • M. Yao, Y. Kow
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TLDR
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