Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalis.

@article{Guentsch2013CleavageOI,
  title={Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalis.},
  author={Arndt Guentsch and Christine Hirsch and Wolfgang Pfister and Bjarne Vincents and Magnus Abrahamson and Aneta Sroka and Jan Potempa and Sigrun Eick},
  journal={Journal of periodontal research},
  year={2013},
  volume={48 4},
  pages={458-65}
}
BACKGROUND AND OBJECTIVES Immunoglobulin (Ig) G1 plays an important role in the adaptive immune response. Kgp, a lysine-specific cysteine protease from Porphyromonas gingivalis, specifically hydrolyses IgG1 heavy chains. The purpose of this study was to examine whether cleavage of IgG1 occurs in gingival crevicular fluid (GCF) in vivo, and whether there is any association with the presence of Porphyromonas gingivalis and other periodontopathogens. MATERIAL AND METHODS GCF was obtained from… CONTINUE READING
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