Cleavage of Dicer Protein by I7 Protease during Vaccinia Virus Infection

@inproceedings{Chen2015CleavageOD,
  title={Cleavage of Dicer Protein by I7 Protease during Vaccinia Virus Infection},
  author={Jhih-Si Chen and H. C. Li and Shu-I Lin and Chee-Hing Yang and Wan-Yu Chien and Ciao-Ling Syu and Shih-Yen Lo},
  booktitle={PloS one},
  year={2015}
}
Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection. Thus, it is possible that Dicer protein is cleaved by a viral protease followed by proteasome degradation of the cleaved… CONTINUE READING